Zithromax (Azithromycin)

infections caused by pathogens susceptible to azithromycin:
ENT infections (sinusitis, pharyngitis, tonsillitis);
lower respiratory tract infections (bronchitis, pneumonia of mild to moderate severity);
otitis media;
infections of skin and soft tissues;
uncomplicated urogenital infections caused by Chlamydia trachomatis.

administered orally 1 time a day for 1 hour before or 2 hours after meals. Upper respiratory tract infections, lower respiratory tract, skin, soft tissues (except for chronic erythema migrans) children Azimed capsules 250 mg is recommended to be used in children weighing 25-50 kg. Assign a rate of 10 mg / kg body weight for 3 days. When the mass of ≥ 50 kg are assigned dose as for adults.

Azithromycin - a representative of a new group of macrolide antibiotics - azalides. Has a broad spectrum antimicrobial (bacteriostatic) action. By the azithromycin susceptible Gram-positive (Streptococcus pneumoniae, S. puogenes, S. agalactiae, S. viridans, Streptococcus group C, F and G, Staphylococcus aureus, S. epidermidis), Gram (Naemophilus influenzae, H. parainfluenzae, Moraxella catarrhalis, Bordetella pertussis , B. parapertussis, Legionella pneumophila, H. ducrei, Campylobacter jejuni, Neisseria gonorrhoeae, Gardnerella vaginalis), some anaerobic (Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp., Peptococcus) microorganisms, as well as Chlamydia trachomatis, Chlamydia pneumoniae, Mycobacteria avium complex , Mycoplasma pneumoniae, Ureaplasma urealyticum and spirochetes (Treponema pallidum, Borrelia burgdorferi). No effect on gram-positive bacteria that are resistant to erythromycin. The antimicrobial action is performed by binding to 50S-subunit of the ribosome, oppression peptidtranslokazy on the stage of translation, and suppression of protein biosynthesis, which leads to stunted growth and reproduction of bacteria. Azithromycin is rapidly absorbed from the gastrointestinal tract, due to its stability in acidic medium and lipophilicity. C max in serum levels achieved after 2,5-2,96 h and 0.4 mg / L when administered 0.5 g of azithromycin. After a single dose of 0.5 g of the drug bioavailability - 37%. The drug penetrates well into the respiratory tract, organs and tissues of the urogenital tract, particularly in the prostate, a skin and soft tissue. The concentration of drug in tissues and cells is 10-15 times higher than in serum. T ½ is 68 h. The high concentration in tissues and slow elimination from tissues due to low binding of azithromycin to plasma proteins, as well as the ability to penetrate into eukaryotic cells and concentrate in an environment with low pH, environmental lysosomes. It defines, in turn, a large apparent volume of distribution (31.1 L / kg) and high plasmatic clearance. We prove that the phagocytes deliver the drug to the site of infection, where its release. Good penetration of azithromycin into cells and accumulate in the phagocytes, which is transported in inflammation, promotes antimicrobial activity of the drug. Despite the high concentration in phagocytes, azithromycin did not significantly affect their function. Elimination of azithromycin from plasma is carried out in two stages: T ½ is 14-20 hours between 8 and 24 h after dosing and 41 hours - in the range of 24 to 72 hours, which allows you to use a drug once a day. Food intake significantly alters the pharmacokinetics: lower C max of the drug in plasma by 52%. Azithromycin demethylation in the liver produced metabolites are inactive. Excreted in the bile: 50% unchanged, and 6% - in the urine. In older men (65-85 years) pharmacokinetic parameters are not changed for women - increases Cmax of the drug in plasma by 30-50%.

If you miss a dose of Zithromax, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Zithromax pills store at temperatures above 25 ° C.